Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells.
Lin HJ, Zuo T, Lin CH, Kuo CT, Liyanarachchi S, Sun S, Shen R, Deatherage DE, Potter D, Asamoto L, Lin S, Yan PS, Cheng AL, Ostrowski MC, Huang TH.
Lin HJ, et al.
Cancer Res. 2008 Dec 15;68(24):10257-66. doi: 10.1158/0008-5472.CAN-08-0288.
Cancer Res. 2008.
PMID: 19074894
Free PMC article.
Less is known about the upstream initiators that direct this process. Here, we report that the Cystatin M (CST6) tumor suppressor gene is concurrently down-regulated with other loci in breast epithelial cells cocultured with cancer-associated fibroblasts (CAF). ...
Less is known about the upstream initiators that direct this process. Here, we report that the Cystatin M (CST6) tumor suppressor gen …